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Publications & Research

Neuroreader® is supported by a growing body of peer-reviewed research and independent validation studies. Below is a curated list of key publications demonstrating the accuracy, clinical utility, and scientific foundation of automated brain volumetric analysis.

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Neuroreader® Brain Volumetric Report Reduces Time to Diagnosis

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Neuroreader® Related Literature


Predictive Utility of Marketed Volumetric Software Tools in Subjects at Risk for Alzheimer Disease
T. P. Tanpitukpongse, M.A. Mazurowaki, J. Ikhena, J.R. Petrella, for the Alzheimer’s Disease Neuroimaging Initiative
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Progressive Focal Gray Matter Volume Loss in a Former High School Football Player: A Possible MRI Volumetric Signature for Chronic Traumatic Encephalopathy
Cyrus A. Raji, David A. Merrill, Jorge R. Barrio, Bennet Omalu, Gary W. Small
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Quantitative Neuroimaging Software for Clinical Assessment of Hippocampal Volumes on MR Imaging
Ahdidan, Raji, DeYoe, Mathis, Noe, Rimestad, Kjeldsen, Mosegaard, Becker, Lopez

Journal of Alzheimer’s Disease, vol. 49, no. 3, pp. 723-732, 2015Read A​​​​rticle ​​→


MRI Monitor: Neuroradiology Quantification Software Available
C. Snyder, Radiology Today; Vol. 17 No. 1, Jan 2016Read A​​​​rticle ​​→


Background Literature


Integrating Longitudinal Information in Hippocampal Volume Measurements for the Early Detection of Alzheimer’s Disease
A. Chincarini, F. Sensi, L. Rei, G. Gemme, S. Squarcia, R. Longo, F. Brun, S. Tangaro, R. Bellotti, N. Amoroso, M. Bocchetta, A. Redolfi, P. Bosco, M. Boccardi, G. Frisoni, F. Nobili, for the ADNI

NeuroImage, Volume 125, 15 Jan 2016, Pages 834–847

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Neuroimaging Distinction Between Neurological and Psychiatric Disorders
N.A. Crossley, J. Scott, I. Ellison-Wright, A. Mechelli

The British Journal of Psychiatry, 2015; 207(5):429–434

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Preventive Neuroradiology in Brain Aging and Cognitive Decline
C.A. Raji, H. Eyre, S.H. Wei, D.E. Bredesen, S. Moylan, M. Law, G. Small, P.M. Thompson, R.M. Friedlander, D.H. Silverman, B.T. Baune, T.A. Hoang, N. Salamon, A.W. Toga, M.W. Vernooij

AJNR Am J Neuroradiol, 36:1803–1809, Oct 2015

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The EADC-ADNI Harmonized Protocol for Manual Hippocampal Segmentation on MRI: Evidence of Validity
G.B. Frisoni, C.R. Jack Jr., M. Bocchetta, C. Bauer, K.S. Frederiksen, Y. Liu, G. Preboske, T. Swihart, M. Blair, E. Cavedo, M.J. Grothe, M. Lanfredi, O. Martinez, M. Nishikawa, M. Portegies, T. Stoub, C. Ward, L.G. Apostolova, R. Ganzola, D. Wolf, F. Barkhof, G. Bartzokis, C. DeCarli, J. Csernansky, L. deToledo-Morrell, M.I. Geerlings, J. Kaye, R. Killiany, S. Lehéricy, H. Matsuda, J. O’Brien, L.C. Silbert, P. Scheltens, H. Soininen, S. Teipel, G. Waldemar, A. Fellgiebel, J. Barnes, M. Firbank, L. Gerritsen, W. Henneman, N. Malykhin, J.C. Pruessner, L. Wang, C. Watson, H. Wolf, M. de Leon, J. Pantel, C. Ferrari, P. Bosco, P. Pasqualetti, S. Duchesne, H. Duvernoy, M. Boccardi, for the EADC-ADNI Working Group

Alzheimer’s & Dementia, Feb 2015; 11(2):111–125

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Delphi Definition of the EADC-ADNI Harmonized Protocol for Hippocampal Segmentation
M. Boccardi, M. Bocchetta, L.G. Apostolova, J. Barnes, G. Bartzokis, G. Corbetta, C. DeCarli, L. deToledo-Morrell, M. Firbank, R. Ganzola, L. Gerritsen, W. Henneman, R. Killiany, N. Malykhin, P. Pasqualetti, J.C. Pruessner, A. Redolfi, N. Robitaille, H. Soininen, D. Tolomeo, L. Wang, C. Watson, H. Wolf, H. Duvernoy, S. Duchesne, C.R. Jack Jr., G.B. Frisoni, for the EADC-ADNI Working Group

Alzheimer’s & Dementia, Feb 2015; 11(2):126–138

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Survey of Protocols for the Manual Segmentation of the Hippocampus: Towards a Joint EADC-ADNI Harmonized Protocol
M. Boccardi, R. Ganzola, M. Bocchetta, M. Pievani, A. Redolfi, G. Bartzokis, R. Camicioli, J.G. Csernansky, M.J. de Leon, L. deToledo-Morrell, R.J. Killiany, S. Lehéricy, J. Pantel, J.C. Pruessner, H. Soininen, C. Watson, S. Duchesne, C.R. Jack Jr., G.B. Frisoni

Journal of Alzheimer’s Disease, 2011; 26(Suppl 3):61–75

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Longitudinal MRI Study of Brain Structure and Hippocampal Volume in Major Depressive Disorder
J. Ahdidan, L.B. Hviid, M.M. Chakravarty, B. Ravnkilde, R. Rosenberg, A. Rodell, H. Stødkilde-Jørgensen, P. Videbech

Acta Psychiatrica Scandinavica, Volume 123, Issue 3, March 2011, Pages 211–219

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Automated Cross-Sectional and Longitudinal Hippocampal Volume Measurement in Mild Cognitive Impairment and Alzheimer’s Disease
K.K. Leung, J. Barnes, G.R. Ridgway, J.W. Bartlett, M.J. Clarkson, K. Macdonald, N. Schuff, N.C. Fox, S. Ourselin, for the ADNI

NeuroImage, Jul 2010; 51(4):1345–1359

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Comparing 3T and 1.5T MRI for Tracking Alzheimer’s Disease
A.J. Ho, X. Hua, S. Lee, A.D. Leow, I. Yanovsky, B. Gutman, I. Dinov, N. Leporé, J.L. Stein, A.W. Toga, C.R. Jack Jr., M.A. Bernstein, E.M. Reiman, D.J. Harvey, J. Kornak, N. Schuff, G.E. Alexander, M.W. Weiner, P.M. Thompson, for the ADNI

Human Brain Mapping, Apr 2010; 31(4):499–514

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Age, Alzheimer’s Disease, and Brain Structure
C.A. Raji, O.L. Lopez, L.H. Kuller, O.T. Carmichael, J.T. Becker

Neurology, Dec 2009; 73(22):1899–1905

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MR-Based In Vivo Hippocampal Volumetrics: 2. Findings in Neuropsychiatric Disorders
E. Geuze, E. Vermetten, J.D. Bremner

Molecular Psychiatry, 2005; 10:160–184

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MR-Based In Vivo Hippocampal Volumetrics: 1. Review of Methodologies
E. Geuze, E. Vermetten, J.D. Bremner

Molecular Psychiatry, 2005; 10:147–159

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Structural MRI in the Practical Assessment of Dementia
P. Scheltens, N. Fox, F. Barkhof, C. DeCarli

The Lancet Neurology, Volume 1, Issue 1, May 2002, Pages 13–21

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Practice Parameter – Diagnosis of Dementia
D.S. Knopman, S.T. DeKosky, J.L. Cummings, H. Chui, J. Corey–Bloom, N. Relkin, G.W. Small, B. Miller, J.C. Stevens

Neurology, May 2001; 56(9):1143–1153

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