Volumetric MRI Basics
Volumetric MRI is a method of brain imaging that quantitatively measures the size of specific brain structures. It provides objective data rather than relying solely on visual interpretation of MRI images.
A regular MRI is typically interpreted visually, while volumetric MRI adds automated measurement of brain volumes, enabling detection of subtle structural changes that may not be visible to the human eye.
Volumetric MRI measures the volume of specific brain regions, such as the hippocampus, lobes, ventricles, and total brain volume, using standardized algorithms.
Volumetric MRI provides objective, reproducible data that can help clinicians assess brain atrophy, monitor changes over time, and support clinical decision-making.
Neuroreader Overview
Neuroreader® is FDA-cleared and CE-marked medical software that automatically analyzes brain MRI scans and produces a quantitative volumetric report in under 10 minutes.
Neuroreader® converts standard brain MRI scans into objective brain volume measurements, helping clinicians assess brain structure more consistently and efficiently.
Neuroreader® post-processes a 3D T1-weighted MRI, segments brain structures, measures their volumes, and compares results to a validated normative database adjusted for age, sex, and head size.
Neuroreader® quantifies 83 brain structures, including the hippocampus, cortical lobes, ventricles, and whole brain volume.
Once MRI images are received, Neuroreader® typically generates a complete report in less than 10 minutes, depending on image quality.
MRI Scan Requirements
No. Neuroreader® does not change the MRI exam, scanning time, or patient experience. Analysis occurs after the scan is completed.
No. Neuroreader® uses non-contrast 3D T1-weighted MRI sequences. Contrast is not required and may affect segmentation quality.
A volumetric 3D T1 sequence is required, such as MPRAGE (Siemens) or BRAVO/SPGR (GE), with 1.0 mm slices (maximum 1.2 mm).
Neuroreader® supports 1.5T and 3T MRI scanners. For longitudinal studies, consistent scanner settings are recommended.
Clinical Use & Conditions
Volumetric MRI is commonly used to support evaluation of neurodegenerative disease, cognitive impairment, and traumatic brain injury, and to monitor structural change over time.
Volumetric MRI can quantify brain atrophy by measuring reductions in specific brain regions relative to normative data.
Volumetric MRI can quantify brain atrophy by measuring reductions in specific brain regions relative to normative data.
Yes. Volumetric MRI is often used to assess brain regions commonly affected in Alzheimer’s disease, such as the hippocampus.
Reports & Data Interpretation
A Neuroreader® report includes brain volume measurements, statistical comparisons, segmented images, charts, and summary tables.
The normative database consists of MRI scans from healthy individuals and is used to statistically compare patient brain volumes.
Patient brain volumes are compared to the normative database using percentiles, z-scores, and indices adjusted for age, sex, and head size.
Neuroreader® statistically adjusts volume comparisons using measured total intracranial volume (mTIV), age, and sex to ensure accurate normalization.
Workflow & Integration
Neuroreader® integrates via secure web access, PACS integration, on-site mediation servers, or AI marketplaces, depending on workflow needs.
Yes. Neuroreader® reports can be returned directly to PACS and zero-footprint viewers.
Neuroreader® is available as both cloud-based and on-premise (mediation server) solutions.
Reports are delivered electronically through PACS, web portals, or integrated clinical systems.
Regulatory & Compliance
Yes. Neuroreader® is FDA-cleared (Class II) and CE-marked, and Brainreader is ISO 13485 certified and HIPAA compliant.
Yes. Neuroreader® is CE marked as a medical device and complies with applicable European medical device regulations.
Yes. All personal health information processed by Neuroreader® is handled in accordance with HIPAA requirements.
No. Neuroreader® is a clinical decision-support tool and must be interpreted by a qualified physician in clinical context.
Security & Data Handling
They’re retained temporarily (a few days), not backed up, and deleted after analysis for data protection.
Only a standard server environment (64-bit, 4GB RAM, 500GB storage). Compatible with Linux, Windows, and macOS.
Yes—an automatic check ensures each scan meets requirements. Any issues prompt a clear on-screen message.
You'll get immediate in-app feedback explaining the problem and how to correct it.
Ordering & Access
Physicians order a standard brain MRI and specify a 3D volumetric T1 sequence for volumetric analysis.
Neuroreader® reports are requested by ordering physicians and imaging centers as part of a clinical MRI workflow.
About Brainreader
Brainreader is a global leader in automated brain volumetric imaging, developing FDA-cleared software that transforms MRI scans into objective brain health insights.
Neuroreader® was developed by Brainreader and has been used in clinical practice and peer-reviewed research since 2011.
Brainreader has specialized in brain volumetrics for over a decade, focusing on clinical-grade, automated MRI analysis.