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Early Detection of Neurodegenerative Disease with Neuroreader®

Dementia affects 50 million people worldwide and costs the U.S. healthcare system more than 818 billion US dollars annually. Yet 80% of those who meet the diagnostic criteria for dementia have not received a proper diagnosis. In fact, only 16% of adults over 65 are routinely assessed forthis form of neurodegeneration.


To address these and other unmet needs in neurodegenerative disease diagnoses and treatments, Brainreader has developed Neuroreader®, a ground-breaking, FDA cleared, and

CE marked software-based assessment tool that can detect abnormal brain patterns in MRI

scans as accurately as manual segmentation in a fraction of the time.

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8 Benefits of Neuroreader®Inside the Neuroreader® Report Workflow & Protocol

8 Benefits of Neuroreader®


  1. Comprehensive analysis – Quantifies 83 brain volumes (e.g., hippocampus, ventricles, lobes)
  2. Fast results – Computes the entire brain in under 10 minutes
  3. Objective data – Provides volume comparisons against demographic norms
  4. Early detection – Identifies sensitive biomarkers of neurodegenerative disease
  5. Progress tracking – Generates longitudinal reports to monitor change over time
  6. Seamless adoption – Easy for all clinicians; integrates with PACS or browser workflows​
  7. Actionable insights – Reliable measurements to guide diagnosis and treatment planning
  8. Versatile use – Ideal for both clinical practice and research studies

Inside the Neuroreader® Report


Every report includes:

  • Total Intracranial Volume (mTIV)
  • Left-Right Asymmetry Index (13 structures)
  • Brain volume assessment of 64+ volumes (mL, percentiles, Z-scores, etc.)
  • Quality assessment images for scan reliability
  • Brain heat maps highlighting percentile values and areas of concern
  • Charts for selected brain structures
  • Longitudinal charts (with mediation server)
  • 2D/3D overlays in NIfTI and DICOM formats
  • JSON values for research purposes

Workflow & Protocol


  • MRI performed on 1.5T or 3.0T scanner
  • Acquire 3D T1 sequence without contrast
  • Images uploaded securely to the Brainreader server or PACS integration
  • Neuroreader® automatically segments and measures brain structures
  • FDA-cleared normative database used for statistical comparison
  • Customized report generated and returned in <10 minutes

Contact us for Neuroreader® MRI protocol details.

How Neuroreader® fits into the patient journey:

Early detection of neurodegenerative disease is not only valuable for clinicians, it also empowers patients and families to understand their options sooner, plan ahead, and begin treatment earlier.

MRI Acquisition

A 3D T1 MRI is performed by the technologist

Secure Upload

The MRI center uploads the scan to the Neuroreader® system

Automated Analysis

The software processes the scan and quantifies 65+ structures

Report Generation

A detailed report is generated and delivered back to PACS or web portal

Clinical Review

Radiologists and referring physicians gain actionable volumetric insights

Patient Care

Patients receive earlier diagnosis, improved education, and better treatment options

Do you want to know more about our software?

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